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Five 49ers you should watch vs. Saints in Week 2 matchup of 2025 NFL season

Published Sep 12, 2025 at 8:20 AM
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The 49ers will have neither quarterback Brock Purdy nor his favorite target, tight end George Kittle, on Sunday against the New Orleans Saints.Purdy made it through the entire game with a toe injury, while Kittle exited in the first half with his hamstring injury. He caught a touchdown pass before sustaining the injury.Still, the 49ers emerged from Week 1 of the NFL season with a 17-13 victory over the Seattle Seahawks.In addition to a mix of their veteran stars, the 49ers got some key contributions from under-the-radar players.Defensive end Sam Okuayinonu came up with a big play when he forced a fourth-quarter fumble. The 49ers scored the winning points on tight end Jake Tonges’ amazing touchdown catch, ripped from the grasp of Seattle defensive back Riq Woolen.The 49ers may need more of the same on Sunday against the Saints, who opened the Kellen Moore era with a 20-13 loss to the Arizona Cardinals.Here are five 49ers to watch, as the team expects nothing to come easy in the Big Easy.QB Mac JonesIt is coming four years after many anticipated, but Mac Jones will finally make his first start as a member of the 49ers.Coach Kyle Shanahan was a known admirer of Jones before the...

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