Each week, 49ers Webzone staff members participate in the NFL Pick 'em contest, predicting winners for every NFL game. For Week 12, six out of seven staff members picked the Packers to beat the 49ers, leaving just one confident in San Francisco pulling off the upset.
Among the fans participating in the NFL Pick 'Em contest, 55% have also chosen the Packers to emerge victorious, as of this post, marking the first time fans have favored a 49ers opponent this season. This change is likely influenced by the 49ers ruling out starting quarterback Brock Purdy for the game.
Most One-Sided Matchup: Chiefs at Panthers
Two Week 12 games stand out as the most lopsided in terms of predictions. An overwhelming 98% believe the Kansas City Chiefs will dominate the Carolina Panthers, while the same percentage expects the Houston Texans to triumph over the Tennessee Titans.
Most Competitive Matchup: Cardinals at Seahawks
The closest contest in terms of fan predictions is the NFC West clash between the Arizona Cardinals and the Seattle Seahawks. This matchup is a virtual coin toss, with 50% of participants picking each team.
Week 12 NFL Matchups
Below is a breakdown of all 12 matchups for the upcoming slate of NFL games.
| Picks | Away | Home | Picks |
|---|---|---|---|
|
87%
|
Vikings
|
Bears
|
13%
|
|
97%
|
Lions
|
Colts
|
3%
|
|
6%
|
Patriots
|
Dolphins
|
94%
|
|
95%
|
Buccaneers
|
Giants
|
5%
|
|
7%
|
Cowboys
|
Commanders
|
93%
|
|
98%
|
Chiefs
|
Panthers
|
2%
|
|
2%
|
Titans
|
Texans
|
98%
|
|
85%
|
Broncos
|
Raiders
|
15%
|
|
45%
|
49ers
|
Packers
|
55%
|
|
50%
|
Cardinals
|
Seahawks
|
50%
|
|
79%
|
Eagles
|
Rams
|
21%
|
|
62%
|
Ravens
|
Chargers
|
38%
|
More San Francisco 49ers News
-
Should 49ers fans be concerned about Nick Bosa's absence?
There is a fine line between being concerned about something and simply wondering if there is more to the story. When it comes to Nick Bosa, San Francisco 49ers fans have every right to be wondering right now. The 49ers have listed Bosa as dealing with soreness, and Kyle... -
49ers training camp: Brock Purdy, Mac Jones shine in practice as WR chemistry grows
The San Francisco 49ers held their 13th full training camp practice on Sunday as they continued preparations for the 2026 NFL season. It was the final practice open to fans and the last practice before Tuesday's joint session with the Los Angeles Chargers in El Segundo,... -
Kyle Shanahan, Brock Purdy share updates after 49ers-Titans joint practice
San Francisco 49ers head coach Kyle Shanahan and quarterback Brock Purdy spoke with reporters after Tuesday's joint practice with the Tennessee Titans. Here's everything they had to say. Transcripts provided by the San Francisco 49ers Communications staff. Head Coach Kyle... -
49ers training camp: Titans joint practice sparks fights; Defense, Brock Purdy shine
The San Francisco 49ers held their 11th full training camp practice on Tuesday as they continued preparations for the 2026 NFL season. The practice was a joint session with the Tennessee Titans, whom the 49ers will face in Thursday night's preseason opener. Head coach Kyle...