Brandon Aiyuk is not ready to return yet. Almost two weeks after Kyle Shanahan said the star wide receiver was close to having his 21-day practice window opened, the 49ers coach said it won't be this week.Aiyuk remains on the reserve/physically unable to perform list as he continues to work his way back from ACL and MCL tears in his knee. He was injured Oct. 20, 2024, in a game against the Chiefs.The 49ers continue to say Aiyuk is "making progress" in his rehab, but more than a year after his injury, Aiyuk still is not back on the practice field.The 49ers off week is Week 14.Aiyuk had back-to-back 1,000-yard seasons in 2022 and 2023 before playing only seven games last season. He finished 2024 with 25 catches for 374 yards.
Brandon Aiyuk won’t have his 21-day practice window opened this week
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49ers injury news: Shanahan on severity of Mykel Williams' torn ACL; Still no Aiyuk; Huff, Pearsall updates
By David Bonilla
Nov 3, 2025
ESPN's Jeremy Fowler was the first to report that San Francisco 49ers head coach Kyle Shanahan's fears from Sunday afternoon were confirmed—rookie defensive end Mykel Williams suffered a torn ACL and will undergo season-ending surgery.
Shanahan spoke with reporters via...
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