Williams suffered a hamstring injury on the first offensive play of the 49ers' Week 17 game against the Chicago Bears, forcing him to miss Week 18's matchup against the Seattle Seahawks.
He is among several players who will not practice on Wednesday, the team's first on-field session of the week. Typically, Williams receives a rest day on the first practice day, but Shanahan confirmed his absence is injury-related.
"No, he's still hurt," Shanahan said. "Hopefully, he'll be better and can get something in tomorrow, but I'm not sure where he'll be at tomorrow yet."
Others sitting out Wednesday include wide receiver Ricky Pearsall (knee, ankle), linebacker Dee Winters (ankle), and defensive end Keion White (groin, hamstring).
Shanahan clarified that Pearsall aggravated his PCL injury during the game against Chicago, not in practice last week, placing him in a similar situation to Williams regarding availability for Sunday.
Tight end George Kittle (ankle), defensive end Yetur Gross-Matos (knee), and linebacker Luke Gifford (quad) are expected to be limited practice participants.
San Francisco also opened the practice window for wide receiver Jacob Cowing, though Shanahan expressed doubt about his chances of playing this weekend.
"We've got him for three weeks, so I'd say there's a chance to get him back in and see what happens over these three weeks," Shanahan said. "But for a guy to not have any practice throughout camp or this regular season, I think it'd be a little unrealistic for this week."
Related News
More San Francisco 49ers News
-
49ers WR Ricky Pearsall enters pivotal season with future on the line
There is little doubt that San Francisco 49ers wide receiver Ricky Pearsall has the talent to become a dangerous weapon in head coach Kyle Shanahan's offense. Since arriving in Santa Clara, the former first-round draft pick has consistently impressed during offseason practices... -
49ers prediction casts doubt over Ricky Pearsall's future
The 2026 season could be a pivotal one for San Francisco 49ers wide receiver Ricky Pearsall. The former first-round pick has shown flashes of potential, but injuries have limited his opportunities to establish himself as a consistent contributor. The 49ers selected Pearsall... -
Where 49ers' Trent Williams landed in ESPN's offensive tackle rankings
San Francisco 49ers left tackle Trent Williams is under contract through the 2027 season and has acknowledged that this will likely be the final deal of his NFL career. If that's the case, the 49ers can expect at least two more seasons of elite blindside protection for... -
49ers face O-line questions as Trent Williams inches closer to retirement
San Francisco 49ers left tackle Trent Williams is under contract through the 2027 season, giving fans at least two more years to watch the future Hall of Famer protect franchise quarterback Brock Purdy's blind side. Earlier this offseason, Williams acknowledged that his...