Inactives:
- LB Tatum Bethune (ankle)
- DT Jordan Elliott (knee)
- RB Jordan James
- LB Nick Martin (concussion)
- DE Sam Okuayinonu (ankle)
- DL Sebastian Valdez
- WR Jordan Watkins
Just hours before kickoff, the 49ers announced that defensive tackle Jordan Elliott would not play due to a knee injury that, according to the team, occurred on Sunday.
On Friday, the 49ers ruled out three players from the active roster: defensive end Sam Okuayinonu and linebackers Tatum Bethune and Nick Martin. The team also announced that defensive end Yetur Gross-Matos (hamstring) and quarterback Kurtis Rourke (knee), whose practice windows were recently opened, would not play.
On Saturday, the 49ers elevated linebacker Jalen Graham and defensive lineman Sebastian Valdez from the practice squad. However, Valdez is inactive for the game. The team also placed wide receiver Brandon Aiyuk on the reserve/left list, officially ending his chances of returning this season.
San Francisco also listed running back Christian McCaffrey as questionable with a back injury. However, he is active and will play against the Titans.
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