San Francisco 49ers
Questionable
- CB Deommodore Lenoir (calf)
Arizona Cardinals
Out
- LB Baron Browning (concussion)
- G Hayden Conner (knee)
- WR Marvin Harrison (illness)
- CB Will Johnson (back, hip)
- S Dadrion Taylor-Demerson (ankle)
- T Jonah Williams (shoulder)
- LB Mack Wilson (ribs)
Questionable
- T Kelvin Beachum (not injury related - resting player, groin)
- G Will Hernandez (knee)
- RB Zonovan Knight (ankle)
- DT Walter Nolen (knee)
- LB B.J. Ojulari (knee)
- DT Darius Robinson (groin)
Injury Notes
The biggest takeaway from Friday's 49ers practice was the absence of cornerback Deommodore Lenoir, who first appeared on Thursday's injury report with a calf issue. He's listed as questionable for Sunday's game.
Head coach Kyle Shanahan confirmed Lenoir's injury occurred during practice on Thursday.
"He tried to go today, didn't," Shanahan said. "He'll get an MRI here. Didn't think it was that serious. Did a jog-in from a drill—just some tightness. We'll find more when we get an MRI."
Brock Purdy is set to return as the starting quarterback after participating fully in practice on Thursday and Friday. Sunday will mark his first game action since Week 4, when he aggravated a turf toe injury.
"I thought it was an awesome week for him," Shanahan said. "Just getting back to do what he does, do what we do, and do it aggressively."
Wide receiver Ricky Pearsall also looks set to play for the first time since Week 4, when he suffered a knee injury.
Additionally, rookie defensive tackle Alfred Collins, who missed Week 10 with a hip injury, has been cleared to play against the Cardinals.
Below are Friday's practice participation reports for both the 49ers and Cardinals, which were provided by the 49ers Communications staff.
San Francisco 49ers Friday Practice
Did Not Participate In Practice
- CB Deommodore Lenoir (calf)
Full Participation in Practice
- DT Alfred Collins (hip)
- QB Mac Jones (knee, knee)
- RB Christian McCaffrey (not injury related - resting player)
- WR Ricky Pearsall (knee)
- QB Brock Purdy (toe)
- T Trent Williams (not injury related - resting player)
- LB Dee Winters (knee, knee)
Arizona Cardinals Friday Practice
Did Not Participate In Practice
- LB Baron Browning (concussion)
- DT Calais Campbell (not injury related - resting player)
- WR Marvin Harrison (illness)
- CB Will Johnson (back, hip)
- S Dadrion Taylor-Demerson (ankle)
- T Jonah Williams (shoulder)
- LB Mack Wilson (ribs)
Limited Participation in Practice
- T Kelvin Beachum (not injury related - resting player, groin)
- G Hayden Conner (knee)
- G Will Hernandez (knee)
- RB Zonovan Knight (ankle)
- DT Walter Nolen (knee)
- LB B.J. Ojulari (knee)
- DT Darius Robinson (groin)
- LB Josh Sweat (not injury related - resting player, knee)
Full Participation in Practice
- G Evan Brown (foot)
- CB Max Melton (concussion)
- WR Xavier Weaver (ankle)
Related News
More San Francisco 49ers News
-
Watch: 49ers WR Ricky Pearsall gears up to silence doubters in 2026
San Francisco 49ers veterans report to training camp on Saturday, and for wide receiver Ricky Pearsall, the 2026 season represents a chance to prove he was worthy of the team's first-round selection in the 2024 NFL Draft. Pearsall has missed 14 games over his first two NFL... -
49ers' Brock Purdy left out of ESPN's top-10 quarterback rankings
The debate over where San Francisco 49ers quarterback Brock Purdy ranks among the NFL's elite continues. ESPN's Jeremy Fowler continued his annual NFL position rankings this week, unveiling his list of the league's top quarterbacks. The rankings are based on feedback from NFL... -
49ers QB Brock Purdy lands surprising spot in 2026 fantasy football rankings
Where does San Francisco 49ers quarterback Brock Purdy rank among the NFL's top fantasy football quarterbacks entering the 2026 season? NFL Media's Dan Parr released his fantasy football quarterback rankings for NFL.com, organizing the league's top signal-callers into draft... -
Former teammate says best is yet to come for 49ers QB Brock Purdy
The debate surrounding San Francisco 49ers quarterback Brock Purdy continues, even a year after he became one of the NFL's highest-paid players. Despite his accomplishments, questions persist about where Purdy belongs among the league's elite quarterbacks. Purdy was left off...