Speaking to reporters after the game, head coach Kyle Shanahan shared the team's concern that Guerendo may have suffered an MCL injury.
"Not sure yet," Shanahan said. "Most likely an MCL, but we're going to have to find out for sure tomorrow."
Shanahan acknowledged the difficulty of losing Guerendo so early in the game. With only two other running backs suited up—Patrick Taylor, who stepped in for Guerendo, and fullback Kyle Juszczyk—the team was left thin at the position.
"It was tough, especially when you go out on a cart," Shanahan said. "I think that messed with everyone a little bit, but we're still holding out hope that it's good news, or good news in comparison to going off on a cart and everything. Hoping it's not an ACL."
Other injuries
Shanahan also provided updates on several other injuries:
- Safety Malik Mustapha sustained a cut and bruising to his knee and did not return.
- Safety Talanoa Hufanga left the game with a concussion and did not return.
- Cornerback Renardo Green exited with a groin injury and did not return.
- Tackle Colton McKivitz suffered an ankle injury and did not return.
- Wide receiver Chris Conley injured his elbow but returned to the game.
More San Francisco 49ers News
-
Where 49ers' Fred Warner landed in ESPN's off-ball linebacker rankings after injury
San Francisco 49ers linebacker Fred Warner remains one of the NFL's most respected defensive players. Although he missed 11 games last season after suffering a dislocated and fractured right ankle, the All-Pro linebacker still earned the top spot in a prominent offseason... -
49ers' Kyle Juszczyk shares encouraging George Kittle injury recovery update
San Francisco 49ers tight end George Kittle continues to make encouraging progress in his recovery from the Achilles injury he suffered during last season's playoffs. After looking sharp during on-field workouts at Tight End University (TEU), optimism continues to grow that... -
49ers and Brandon Aiyuk: The drama has become repetitive
When he became the starter during his rookie year, quarterback Brock Purdy was consistently referred to by his draft-day moniker, "Mr. Irrelevant." As the Niners won and continued to win while he was the starter, reporters used the same phrase over and over again—that Purdy... -
49ers' Brock Purdy left out of ESPN's top-10 quarterback rankings
The debate over where San Francisco 49ers quarterback Brock Purdy ranks among the NFL's elite continues. ESPN's Jeremy Fowler continued his annual NFL position rankings this week, unveiling his list of the league's top quarterbacks. The rankings are based on feedback from NFL...