San Francisco 49ers (0–4) vs. Indianapolis Colts (1–3)
After losing in overtime in a tough divisional matchup last week against the Cardinals, perhaps the 49ers finally get it right. They're playing a Colts team that just got destroyed against the Seahawks and is still without its franchise quarterback, Andrew Luck. Still, the 49ers' passing offense continues to sputter under quarterback Brian Hoyer despite solid play from the defense. The 49ers have lost by a combined eight points the last three games.
Key Factors
Rashard Robinson — 49ers cornerback Rashard Robinson has been a disappointment a quarter of the way into the season as he adjusts to the 49ers' zone coverage scheme. Per Pro Football Focus, Robinson is at a lowly 36.3 overall grade, which puts him in the bottom spectrum for defensive backs through four weeks. Between his lack of coverage and costly penalties, opposing quarterbacks are testing the second year cornerback. The Colts are ranked 29th in passing yards under backup quarterback Jacoby Brissett but will surely test Robinson against speedy receiver T.Y. Hilton.
Front Seven — While the offense has struggled, the 49ers' defensive front seven continues to shine. The group is coming off a six-sack performance last week and could have another primetime matchup against a struggling Colts offensive line. The 49ers are ranked fifth in pressure rate thanks to defensive tackle DeForest Buckner, who has been the team's best player at a 93.2 overall PFF ranking — that's the top grade among interior linemen. Off the edge, Solomon Thomas is improving despite his inconsistencies while Elvis Dumervil is coming off a two-sack performance.
Passing Game — As mentioned earlier, the 49ers' passing offense continues to struggle. Brian Hoyer has only thrown touchdowns in one game as it seems like he is being overly cautious with the football; he had Trent Taylor open for the score in overtime last week but threw it away. The pass protection — rated 10th overall in pass blocking efficiency (80.5)— has been good enough for Hoyer, it's more so the execution of the unit. The 49ers continue to shoot themselves in the foot with penalties and drops as the team struggles to move the chains to the tune of a 30-percent third-down conversion rate. The 49ers' Pierre Garçon should fare much better this week against his former team as the Colts are giving up the fourth most yards through the air. However, be on the lookout for Colts rookie safety Malik Hooker. Hooker leads the league with three interceptions while the 49ers' defense has just two picks combined.
Overall Thoughts
Aside from another horrible Hoyer performance — which is entirely possible — or a breakout game from former 49ers running back Frank Gore, the 49ers have the makings of finally getting it right this Sunday. Brissett can be a tricky matchup as a dual-threat quarterback but I'm confident the 49ers' front seven will continue to generate enough pressure. Hopefully, a heavy dosage of Carlos Hyde will set up a sustainable passing game as I don't expect Hoyer to register 49 passing attempts like he did last week.
The odd makers have this game as an even pick 'em, which leads me to go with the 49ers notching their first win of the season.
49ers PK Under 44
49ers 24 Colts 16
Written By:
Justin Wong has been writing for the 49ers Webzone since 2017 while also running an NFC West blog and podcast called Just The West. Feel free to follow him, or direct any inquiries to @JustTheWest on Twitter.
All articles by Justin Wong
@JustTheWest
YouTube Channel
Justin Wong
Justin Wong has been writing for the 49ers Webzone since 2017 while also running an NFC West blog and podcast called Just The West. Feel free to follow him, or direct any inquiries to @JustTheWest on Twitter.
All articles by Justin Wong
More San Francisco 49ers News
-
49ers and Brandon Aiyuk: The drama has become repetitive
When he became the starter during his rookie year, quarterback Brock Purdy was consistently referred to by his draft-day moniker, "Mr. Irrelevant." As the Niners won and continued to win while he was the starter, reporters used the same phrase over and over again—that Purdy... -
Former 49ers star says 'rest in peace' to Brandon Aiyuk's NFL career
Brandon Aiyuk has targeted just about everyone on social media this offseason—the San Francisco 49ers, his former agent, the NFL Players Association, and even his friend, Washington Commanders quarterback Jayden Daniels. Now, one former 49ers standout believes Aiyuk may have... -
49ers QB Brock Purdy lands surprising spot in 2026 fantasy football rankings
Where does San Francisco 49ers quarterback Brock Purdy rank among the NFL's top fantasy football quarterbacks entering the 2026 season? NFL Media's Dan Parr released his fantasy football quarterback rankings for NFL.com, organizing the league's top signal-callers into draft... -
49ers' Brock Purdy left out of ESPN's top-10 quarterback rankings
The debate over where San Francisco 49ers quarterback Brock Purdy ranks among the NFL's elite continues. ESPN's Jeremy Fowler continued his annual NFL position rankings this week, unveiling his list of the league's top quarterbacks. The rankings are based on feedback from NFL...