49ers’ defense abysmal in 45-16 loss to Bills

ORCHARD PARK, N.Y. Safety Eric Reid referred to Sundays game as a must win, as he entered the gameclinging to hope the 49ers could turn things around and make a run at the playoffs.Then, there was the harsh reality.The playoffs are not going to happen for the 49ers this season. That might be about the only certainty that remains for the reeling franchise.The 49ers (1-5) dropped their fifth consecutive game, as the Buffalo Bills pushed them around in a 45-16 victory in front of a delighted home crowd.