The 49ers activated defensive tackle Alfred Collins from the active/physically unable to perform list, the team announced.
Collins passed his physical and practiced on Friday after recovering from offseason shoulder surgery.
He enters his second NFL season after being selected out of Texas in the second round of the 2025 draft. As a rookie, he appeared in 16 games with one start.
Collins totaled 17 tackles, one tackle for loss, one sack, two passes defensed, two forced fumbles and a fumble recovery as a rookie.
Running back Isaac Guerendo (pectoral), tight end George Kittle (Achilles) and defensive end Mykel Williams (ACL) remain on PUP.