Take a closer look at the San Francisco 49ers 2026 opponents, featuring international games, historic rivalries, playoff rematches, and reunions with familiar faces across the NFL.
Key Matchups and Storylines in the 49ers 2026 Schedule
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Full 2026 San Francisco 49ers Schedule Revealed
By David Bonilla
May 14
The NFL unveiled its full 272-game schedule for the 2026 regular season. The season kicks off on Wednesday, September 9, with the defending Super Bowl champion Seattle Seahawks hosting the opener at Lumen Field. The NFL season will conclude with Super Bowl LXI on February 14,...
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