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Week 16 Monday Night Football Statistical Review: 49ers all but end Colts' playoff hopes

Week 16 Monday Night Football Statistical Review: 49ers all but end Colts’ playoff hopes

Published Dec 24, 2025 at 3:00 AM

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The 49ers added insult to injury with a game-sealing pick-six, all but ending the Colts' playoff hopes. Indianapolis has now lost five in a row.

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Week 16 Monday Night Football Statistical Review: 49ers all but end Colts’ playoff hopes

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