The San Francisco 49ers were healthy in the first quarter against the the Indianapolis Colts, but the injuries are piling up in the third quarter.
49ers lose LB who just returned to the lineup to injury on Monday
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49ers vs. Colts injury updates: George Kittle, Tatum Bethune exit the game
By David Bonilla
Dec 22, 2025
The San Francisco 49ers are facing the Indianapolis Colts at Lucas Oil Stadium in Week 16. Below are the latest in-game injury updates for the 49ers. This article will be updated in real time as new information becomes available.
Players are listed in order of most recent...
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