The San Francisco 49ers may win their Week 16 matchup with the Indianapolis Colts, but they lost one of their best players to an injury.
49ers star suffers injury in third quarter of Week 16 battle vs. Colts
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49ers vs. Colts injury updates: George Kittle, Tatum Bethune exit the game
By David Bonilla
Dec 22, 2025
The San Francisco 49ers are facing the Indianapolis Colts at Lucas Oil Stadium in Week 16. Below are the latest in-game injury updates for the 49ers. This article will be updated in real time as new information becomes available.
Players are listed in order of most recent...
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