It was McCaffrey's first meeting against the Panthers, who traded him to the 49ers in 2022.
49ers top Panthers, as Christian McCaffrey beats former team
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49ers Notebook: Christian McCaffrey piling up amazing numbers; Career night for Ji'Ayir Brown; Young defense rises to occasion
By Kirk Larrabee
Nov 24, 2025
While much of the talk after the 49ers' Monday night win over the Carolina Panthers was about the three first-half interceptions thrown by quarterback Brock Purdy, there were also a number of positives to take from the game, starting with the play of the defense.
The 49ers...
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