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Panthers-49ers Monday Night Football Week 12 Preview: Odds, lines, best bets

Published Nov 24, 2025 at 3:40 AM
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Despite being significant underdogs, the Panthers have performed well when taking seven or more points, holding a 2-1 ATS record. The 49ers defense has underperformed in the absence of Fred Warner and Nick Bosa, ranking 29th in EPA per play allowed.

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