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49ers open as home underdogs vs. division rival Rams in Week 10
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49ers vs. Rams in Week 10: How to watch, stream, and listen, plus odds
By Site Staff
Nov 5, 2025
The San Francisco 49ers return to Levi's Stadium to face the Los Angeles Rams in the second of two matchups this season. This marks the 154th all-time meeting between the two teams. The 49ers lead the series 79-71-3 and aim to improve their home record to 38-36-2 against the...
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