The San Francisco 49ers never really got going in their Week 4 loss vs. the Jacksonville Jaguars. Here are the highlights.
49ers vs. Jaguars highlights: San Francisco face plants in NFL Week 4 loss
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49ers vs. Jaguars in Week 4: How to watch, stream, and listen, plus odds
By Site Staff
Sep 24, 2025
The San Francisco 49ers will take on the Jacksonville Jaguars in the second of back-to-back games at Levi's Stadium. This matchup marks the eighth all-time meeting between the two teams, with the 49ers leading the series 5-2 and aiming to improve to 3-0 at home against...
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