Home
News
NFL Week 4 Preview: Schedule, storylines, matchups to watch and betting spreads

NFL Week 4 Preview: Schedule, storylines, matchups to watch and betting spreads

Published Sep 25, 2025 at 3:40 AM

The above videos are auto-populated by an affiliate.

Share Share this on Twitter Share this on Facebook Share this on Threads Share this on Bluesky Flip into Flipboard Share this on Reddit Share via SMS Share Sheet

We break down all 16 matchups for Week 4 the 2025 NFL season, starting with the Seattle Seahawks and Arizona Cardinals.

Read the whole article

The above link leads to an external page. 49ers Webzone has no control over its contents.

Click here and check the box by our name!

49ers injury updates: Mike Evans and De'Zhaun Stribling miss practice

49ers Webzone • 8 hrs
Rapoport provides 49ers injury update on Mike Evans

49ers Webzone • 5 hrs
49ers GM John Lynch opens up about wide receiver situation, injuries

49ers Webzone • 5 hrs
49ers' Fred Warner shares players' reaction to Kyle Shanahan addressing the team

49ers Webzone • 9 hrs
How Kyle Shanahan helped convince Mike Evans to join the 49ers

49ers Webzone • 9 hrs
49ers Training Camp Day 6: Injuries continue to mount, and other quick hits

49ers Webzone • 3 hrs

Click here and check the box by our name!

Writers Wanted

This site is not endorsed, sponsored by, or affiliated with the San Francisco 49ers or NFL Enterprises LLC. “49ers” is a registered trademark of the Forty Niners Football Company LLC. All team and player names mentioned are registered trademarks of the NFL and their respective organizations. Any use of team names, trademarks, logos, or photos is strictly for descriptive purposes. Content and information sourced from other sites remain the property of their respective owners.

NFL Week 4 Preview: Schedule, storylines, matchups to watch and betting spreads

Read Next

Latest

Trending News