How ‘safety blanket’ Christian McCaffrey comforts 49ers QB Mac Jones in huddle

What to Know The 49ers improved to 3-0 on the 2025 NFL season after a 16-15 win over the Arizona Cardinals on Sunday at Levi’s Stadium Mac Jones made his second 49ers start in place of Brock Purdy and completed 27 of 41 passes for 284 yards with one touchdown and one interception, including a 10-play, 63-yard final drive to set up Eddy Piñeiro’s game-winning field goal. Ricky Pearsall was the 49ers’ leading receiver, recording 117 yards on 8 receptions and averaging 14.6 yards per catch. Star edge rusher Nick Bosa was ruled out of the game in the first quarter with a knee injury, and the team is waiting for more tests to determine the severity. Read below for all the game highlights, news, analysis and postgame press conferences from Levi’s Stadium in Santa Clara: