The San Francisco 49ers have had a tough time with the Arizona Cardinals since head coach Kyle Shanahan took over in the 2017 season.
49ers vs. Cardinals: Injury updates, predictions from 49ers Week 3 opponent
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49ers deliver unfortunate injury news on Connor Colby, Jordan Watkins, Spencer Burford
By David Bonilla
Sep 19, 2025
San Francisco 49ers quarterback Brock Purdy (toe) is officially listed as "questionable" for Sunday's game against the Arizona Cardinals. However, head coach Kyle Shanahan admitted it's unlikely Purdy will be healthy enough to start, leaving Mac Jones as the probable Week 3...
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