The 49ers' home opener has their defensive focused on Arizona's Kyler Murray, who threw for four touchdown passes in one win last season and ran for a 50-yard touchdown in another.
Will 49ers’ defense be patient or attack ‘slippery’ nemesis Kyler Murray in home opener?
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49ers defense ready with a plan to contain Kyler Murray
By David Bonilla
Sep 17, 2025
Arizona Cardinals quarterback Kyler Murray has long been a challenge for the San Francisco 49ers defense, thanks to his ability to extend plays with his legs when passing options are limited. With coordinator Robert Saleh back at the helm this offseason, the 49ers hope their...
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