The San Francisco 49ers and the New Orleans Saints face off in Week 2 of the NFL regular season today. Here's where to watch and start time.
What TV channel is 49ers vs. Saints on today? Time, TV schedule for NFL Week 2 game
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49ers vs. Saints in Week 2: How to watch, stream, and listen, plus odds
By Site Staff
Sep 10, 2025
The San Francisco 49ers hit the road for the second consecutive week to face the New Orleans Saints at the Caesars Superdome. This matchup marks the 80th all-time meeting between the two teams. The 49ers lead the series 50-27-2 and aim to improve to 27-15 on the road against...
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