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Rundown of 49ers’ extensive injury list after dramatic preseason win vs. Raiders

Published Aug 18, 2025 at 12:00 PM
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The 49ers experienced a few more injuries in their preseason game Saturday against the Las Vegas Raiders.But coach Kyle Shanahan put a positive spin on the 49ers’ injury situation when he spoke with the media Saturday immediately following his team’s game in Las Vegas.“Hopefully, we get a bunch of guys back here,” Shanahan said. “We didn’t lose anyone for the year or anything like that.“Losing those three guys on offense is tough. But they won’t be out forever, so hopefully they’ll heal up fast.”Here is a look at the 49ers’ injury situation, including updates on all the players whose physical conditions kept them out of the team’s 22-19 victory over the Raiders:— WR Brandon Aiyuk — Aiyuk looked good before the game as various videos surfaced of him running routes and catching passes on the field before the game. Still, he is coming back from a severe knee injury. The most likely scenario is that he opens the season on the physically unable to perform list. He would be ineligible for the first four games. The 49ers have a Thursday game in Week 5, which would make it unlikely he would play with...

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