49ers: No. 1 defense no problem for Garoppolo in 44-33 win over Jaguars

Neither a new playbook, nor an underwhelming supporting cast, nor the NFL's scariest defense can stop Jimmy Garoppolo from winning games for the 49ers. On Sunday, Garoppolo added the most impressive chapter to the storybook start to his 49ers' career by leading his new team to a 44-33 victory over Jacksonville, which clinched the AFC South title before kickoff. The Jaguars (10-5) arrived with a defense that led the NFL in points and passing yards allowed, while leading the league in sacks. No matter. Garoppolo completed 21 of 30 passes for 242 yards with two touchdowns, an interception and a scoring run to lead the 49ers (5-10) to their fourth straight win.