As usual, the 49ers will face each NFC West rival twice. They'll also play the third-place teams from the NFC North (Minnesota Vikings), NFC South (Atlanta Falcons), and AFC East (Miami Dolphins). In addition, San Francisco's schedule includes matchups against every team from the NFC East and AFC West.
The 2026 NFL season will kick off on Wednesday, September 9, with the reigning Super Bowl champion Seattle Seahawks hosting the opener at Lumen Field. The season will conclude with Super Bowl LXI on February 14, 2027, at SoFi Stadium in Inglewood, California—the home of the Los Angeles Rams.
The 49ers are also set to play two international games in the 2026 season. San Francisco will open the year as the road team against the Rams in Melbourne, Australia, marking the NFL's first regular-season game in the country. The team will also host a game against the Vikings in Mexico City later in the season.
Below is a list of confirmed or reported 49ers games, including known dates, times (if available), and sources. Once the NFL officially releases the full schedule, a complete game-by-game breakdown will follow in a separate article.
Known Matchup Dates/Times (All Times Pacific)
- Week 1: at Rams (Sep. 10, 5:35 p.m., Melbourne, Australia, per NFL)
- Week 2: Dolphins (Sep. 20, 1:25 p.m., unconfirmed, @RCDiscussion)
- Week 3: Cardinals (Sep. 27, 1:05 p.m., unconfirmed, @RCDiscussion)
- Week 4: Broncos (Oct. 4, 1:25 p.m., unconfirmed, @RCDiscussion)
- Week 5: at Seahawks (Oct. 11, 1:25 p.m., unconfirmed)
- Week 6: Commanders (Oct. 19, 5:15 p.m., MNF, unconfirmed, @OzzyNFL)
- Week 7: at Falcons (Oct. 25, 10 a.m., unconfirmed, @RCDiscussion)
- Week 8: Bye
- Week 9: Raiders (Nov. 8, 1:05 p.m., unconfirmed, @RCDiscussion)
- Week 10: at Cowboys (Nov. 15, 1:25 p.m., unconfirmed, @OzzyNFL)
- Week 11: Vikings (Nov. 22, 5:20 p.m., SNF, Mexico City, per NFL)
- Week 12: Seahawks (Nov. 29, 1:25 p.m., unconfirmed, @RCDiscussion)
- Week 13: at Giants (Dec. 6, 10 a.m., unconfirmed, @OzzyNFL)
- Week 14: Rams (Dec. 13, 1:25 p.m., unconfirmed, @RCDiscussion)
- Week 15: at Chargers (Dec. 17, 5:15 p.m., TNF, unconfirmed, @RCDiscussion)
- Week 16: at Chiefs (Dec. 27, 1:25 p.m., unconfirmed, @RCDiscussion)
- Week 17: Eagles (Jan. 3, 5:20 p.m., SNF, unconfirmed, @RCDiscussion)
- Week 18: at Cardinals (Jan. 9 or 10, unconfirmed, @RCDiscussion)
Note: Any "unconfirmed" listings should be treated as rumors until verified by an official media source.
Home and Away Opponents
Below are the 49ers' complete home and away opponents for the 2026 NFL season. Those reported above are denoted with a strikethrough.
Home (9)
Las Vegas RaidersDenver BroncosWashington CommandersPhiladelphia EaglesMinnesota VikingsMiami DolphinsArizona CardinalsLos Angeles RamsSeattle Seahawks
Away (8)
Dallas CowboysNew York GiantsKansas City ChiefsLos Angeles ChargersAtlanta FalconsArizona CardinalsLos Angeles RamsSeattle Seahawks
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