As usual, the San Francisco 49ers will face each NFC West rival twice. They'll also play the last-place teams from the NFC North (Bears), NFC East (Giants), and AFC North (Browns). Additionally, their schedule features matchups against every team in both the NFC South and the AFC South.
RELATED
The 2025 NFL season will kick off on Thursday, September 4, with the Super Bowl champion Philadelphia Eagles hosting the Dallas Cowboys at Lincoln Financial Field. The season will conclude with Super Bowl LX on February 8, 2026, at Levi's Stadium in Santa Clara, California—home of the 49ers.
San Francisco avoided any international games this season, as the NFL has announced those matchups. They also won't be playing on Thanksgiving or Christmas.
Below is a list of confirmed or reported 49ers games, including known dates, times (if available), and sources. Once the full schedule is officially released, I'll share a complete breakdown in a separate article.
Known Matchup Dates/Times (All Times Pacific)
- Week 1: at Seahawks (Sep. 7, per Dave Mahler)
- Week 2: at Saints (unconfirmed)
- Week 3: vs. Cardinals (Sep. 21, 1:25 p.m., confirmed)
- Week 4: vs. Jaguars (per Dilla, Bold Take Pod)
- Week 5: at Rams (Oct. 2, 5:15 p.m., TNF, @OzzyNFL)
- Week 6: at Buccaneers (unconfirmed)
- Week 7: vs. Falcons (Oct. 19, 5:20 p.m., SNF, confirmed)
- Week 8: at Texans (unconfirmed)
- Week 9: at Giants (Nov. 2, per Art Stapleton)
- Week 10: vs. Rams (Nov. 9, 1:25 p.m., @OzzyNFL)
- Week 11: at Cardinals (unconfirmed)
- Week 12: vs. Panthers (Nov. 24, 5:15 p.m., MNF, Travis Hancock)
- Week 13: at Browns (unconfirmed)
- Week 14: BYE (unconfirmed)
- Week 15: vs. Titans (Dec. 14, 1:25 p.m., confirmed)
- Week 16: at Colts (Dec. 22, MNF, unconfirmed)
- Week 17: vs. Bears (Dec. 28, SNF, confirmed)
- Week 18: vs. Seahawks (Jan. 3 or 4, Corbin K. Smith)
Note: "Unconfirmed" listings should be treated as rumors until an official media member confirms them. Those marked "confirmed" were previously unconfirmed rumors.
Home/Away Opponents
Below are all of San Francisco's home and away opponents for the 2025 season. Those reported above are denoted with a strikethrough.
Home (8)
Arizona CardinalsLos Angeles RamsSeattle SeahawksAtlanta FalconsCarolina PanthersChicago BearsJacksonville JaguarsTennessee Titans
Away (9)
Arizona CardinalsLos Angeles RamsSeattle SeahawksCleveland BrownsHouston TexansIndianapolis ColtsNew Orleans SaintsNew York GiantsTampa Bay Buccaneers
Related News
More San Francisco 49ers News
-
49ers practice and media schedule ahead of preseason opener vs. Titans
The San Francisco 49ers will hold two full practices this week as they prepare for their preseason matchup against the Tennessee Titans. One of the practices will be a planned joint session in Santa Clara between the 49ers and Titans. Offensive coordinator Klay Kubiak is... -
49ers training camp Week 3: Full practice schedule, media availability, and key dates
San Francisco 49ers players have Tuesday off but will kick off their third week of training camp on Wednesday. Assistant head coach/offensive line Chris Foerster, defensive coordinator Raheem Morris, and offensive coordinator Klay Kubiak are scheduled to speak with the media.... -
49ers announce roster moves ahead of Friday training camp practice
The San Francisco 49ers have signed tight end Josiah Deguara and wide receiver Trenton Irwin to one-year deals. To make room on the roster, the team waived cornerback Derrick Canteen and waived/injured tight end Tanner McLachlan. The 49ers Communications staff provided the... -
49ers injuries continue to mount ahead of Wednesday's training camp practice
The San Francisco 49ers' injury list continues to grow as the team opened Wednesday's training camp practice. According to Cam Inman of the Bay Area News Group, the 49ers will be without fullback Kyle Juszczyk, who suffered a fractured finger. The wide receiver group also...